c-Fos immunoreactivity in prefrontal, basal ganglia and limbic areas of the rat brain after central and peripheral administration of ethanol and its metabolite acetaldehyde.

c-Fos immunoreactivity in prefrontal, basal ganglia and limbic areas of the rat brain after central and peripheral administration of ethanol and its metabolite acetaldehyde.

Considerable evidence indicates that the metabolite of ethanol (EtOH), acetaldehyde, is biologically active. Acetaldehyde can be formed from EtOH peripherally mainly by alcohol dehydrogenase, and also centrally by catalase. EtOH and acetaldehyde show differences in their behavioral effects depending...

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Bibliographic Details
Main Authors: Kristen N. Segovia, Regina eVontell, Laura eLópez-Cruz, John D Salamone, Merce eCorrea
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-05-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Metabolism
Nucleus Accumbens
alcohol
dopamine.
early gen
early gene
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2013.00048/full

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