p53-Dependent Apoptotic Effect of Puromycin via Binding of Ribosomal Protein L5 and L11 to MDM2 and Its Combination Effect with RITA or Doxorubicin

p53-Dependent Apoptotic Effect of Puromycin via Binding of Ribosomal Protein L5 and L11 to MDM2 and Its Combination Effect with RITA or Doxorubicin

Among ribosomal proteins essential for protein synthesis, the functions of ribosomal protein L5 (RPL5) and RPL11 still remain unclear to date. Here, the roles of RPL5 and RPL11 were investigated in association with p53/p21 signaling in the antitumor effect of puromycin mainly in HCT116 and H1299 can...

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Bibliographic Details
Main Authors: Ji Hoon Jung, Hyemin Lee, Ju-Ha Kim, Deok Yong Sim, Hyojin Ahn, Bonglee Kim, Suhwan Chang, Sung-Hoon Kim
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Cancers
Subjects:
Puromycin
RPL5
RPL11
p53
doxorubicin
Online Access:https://www.mdpi.com/2072-6694/11/4/582

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