Methyltransferase‐Like Protein 14 Attenuates Mitochondrial Antiviral Signaling Protein Expression to Negatively Regulate Antiviral Immunity via N6‐methyladenosine Modification

Methyltransferase‐Like Protein 14 Attenuates Mitochondrial Antiviral Signaling Protein Expression to Negatively Regulate Antiviral Immunity via N6‐methyladenosine Modification

Abstract Mitochondrial antiviral signaling (MAVS) protein is the core signaling adaptor in the RNA signaling pathway. Thus, appropriate regulation of MAVS expression is essential for antiviral immunity against RNA virus infection. However, the regulation of MAVS expression at the mRNA level especial...

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Bibliographic Details
Main Authors: Fei Qin, Baoshan Cai, Jian Zhao, Lei Zhang, Yi Zheng, Bingyu Liu, Chengjiang Gao
Format: Article
Language:English
Published: Wiley 2021-08-01
Series:Advanced Science
Subjects:
antiviral immunity
N6‐methyladenosine modification
methyltransferase‐like protein 14
mitochondrial antiviral signaling protein
mRNA stability
Online Access:https://doi.org/10.1002/advs.202100606

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