A sparse autoencoder-based deep neural network for protein solvent accessibility and contact number prediction

• Main Authors: Lei Deng, Chao Fan, Zhiwen Zeng
• Format: Article
• Language: English
• Published: BMC 2017-12-01
• Series: BMC Bioinformatics
• Subjects: Solvent accessibility; Contact number; Deep neural network; Sequence-derived features
• Online Access: http://link.springer.com/article/10.1186/s12859-017-1971-7

Abstract Background Direct prediction of the three-dimensional (3D) structures of proteins from one-dimensional (1D) sequences is a challenging problem. Significant structural characteristics such as solvent accessibility and contact number are essential for deriving restrains in modeling protein folding and protein 3D structure. Thus, accurately predicting these features is a critical step for 3D protein structure building. Results In this study, we present DeepSacon, a computational method that can effectively predict protein solvent accessibility and contact number by using a deep neural network, which is built based on stacked autoencoder and a dropout method. The results demonstrate that our proposed DeepSacon achieves a significant improvement in the prediction quality compared with the state-of-the-art methods. We obtain 0.70 three-state accuracy for solvent accessibility, 0.33 15-state accuracy and 0.74 Pearson Correlation Coefficient (PCC) for the contact number on the 5729 monomeric soluble globular protein dataset. We also evaluate the performance on the CASP11 benchmark dataset, DeepSacon achieves 0.68 three-state accuracy and 0.69 PCC for solvent accessibility and contact number, respectively. Conclusions We have shown that DeepSacon can reliably predict solvent accessibility and contact number with stacked sparse autoencoder and a dropout approach.