Salmonella Infection in Chronic Inflammation and Gastrointestinal Cancer

• Main Authors: Lang Zha, Shari Garrett, Jun Sun
• Format: Article
• Language: English
• Published: MDPI AG 2019-03-01
• Series: Diseases
• Subjects: cancer; dysbiosis; inflammation; infection; Salmonella; microbiome; Wnt/β-catenin
• Online Access: http://www.mdpi.com/2079-9721/7/1/28

Salmonella not only causes acute infections, but can also cause patients to become chronic “asymptomatic” carriers. Salmonella has been verified as a pathogenic factor that contributes to chronic inflammation and carcinogenesis. This review summarizes the acute and chronic Salmonella infection and describes the current research progress of Salmonella infection contributing to inflammatory bowel disease and cancer. Furthermore, this review explores the underlying biological mechanism of the host signaling pathways manipulated by Salmonella effector molecules. Using experimental animal models, researchers have shown that Salmonella infection is related to host biological processes, such as host cell transformation, stem cell maintenance, and changes of the gut microbiota (dysbiosis). Finally, this review discusses the current challenges and future directions in studying Salmonella infection and its association with human diseases.