Unilateral retinopathy post perilesional interferon α2b injections for ocular surface squamous cell carcinoma

• Main Authors: Shiv Dalla, Mary Champion, Radwan Ajlan, John E. Sutphin, Jason A. Sokol
• Format: Article
• Language: English
• Published: Elsevier 2021-12-01
• Series: American Journal of Ophthalmology Case Reports
• Subjects: Interferon α2b; Retinopathy; Ocular squamous neoplasia
• Online Access: http://www.sciencedirect.com/science/article/pii/S245199362100205X

Purpose: To describe the clinical course of a patient presenting with unilateral retinopathy after perilesional interferon alpha injections for treatment of ocular surface squamous cell carcinoma. Observations: A patient, who was being treated with interferon alpha for ocular squamous cell carcinoma, presented with new onset decreased vision in her left eye. Upon examination, she was found to have cotton wool spots and retinal hemorrhages in the affected eye. Conclusions and Importance: Retinopathy is a well-documented side effect of systemic usage of interferon alpha. However, retinopathy has not been well discussed in the scenario of perilesional injections of interferon. It is important for clinicians to monitor for such pathology when using interferon alpha not only systemically, but also locally.