Assessment of male factor involved in recurrent pregnancy loss: A preliminary study

• Main Authors: Rim Frikha, Taoufik Frikha, Nouha Bouayed, Tarek Rebai
• Format: Article
• Language: English
• Published: SpringerOpen 2018-09-01
• Series: Middle East Fertility Society Journal
• Online Access: http://www.sciencedirect.com/science/article/pii/S1110569017301565

This study was conducted to assess the male factor as standard sperm parameters, age and chromosome abnormalities from men whose partners had a history of recurrent pregnancy loss (RPL).A 2 years retrospective study was carried out in 149 couples with 2 or more miscarriages. They referred to as for genetic counseling in the laboratory of histology housed in a Faculty of Medicine of Sfax, with genetic laboratories.Chromosomal analysis was performed using RHG banding in peripheral blood and semen samples were analyzed from men according to World Health Organization guidelines.67 men were selected of a total of 149 couples whose partners were healthy and with normal karyotype. About them, the mean age was 33 years [from 22 to 53], and altered semen parameters were detected in more than 25%.Abnormal karyotype was detected in 4 men with an overall incidence of 5.97%. The commonest abnormalities appear to be reciprocal translocation.So, this data emphasizes the importance of assessment of male factor in addition to standard female factors for evaluating the risk for RPL. Keywords: Semen parameters, Translocation, Recurrent pregnancy loss, Chromosome Y