The role of stress-activated protein kinase signaling in renal pathophysiology

The role of stress-activated protein kinase signaling in renal pathophysiology

Two major stress-activated protein kinases are the p38 mitogen-activated protein kinase (MAPK) and the c-Jun amino terminal kinase (JNK). p38 and JNK are widely expressed in different cell types in various tissues and can be activated by a diverse range of stimuli. Signaling through p38 and JNK is c...

Full description

Bibliographic Details
Main Authors:	F.Y. Ma, J. Liu, D.J. Nikolic-Paterson
Format:	Article
Language:	English
Published:	Associação Brasileira de Divulgação Científica 2009-01-01
Series:	Brazilian Journal of Medical and Biological Research
Subjects:	p38 c-Jun amino terminal kinase Inflammation Fibrosis Apoptosis Renal pathophysiology
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000100006

Similar Items

c-Jun Amino Terminal Kinase Signaling Promotes Aristolochic Acid-Induced Acute Kidney Injury
by: Fan Yang, et al.
Published: (2021-02-01)

Pathophysiological Roles of Stress-Activated Protein Kinases in Pulmonary Fibrosis
by: Yoshitoshi Kasuya, et al.
Published: (2021-06-01)

Role of Jun amino-terminal kinase (JNK) in apoptosis of cavernosal tissue during acute phase after cavernosal nerve injury
by: Won Hoon Song, et al.
Published: (2018-01-01)

Antitumor effect of Quercetin on Y79 retinoblastoma cells via activation of JNK and p38 MAPK pathways
by: Haojie Liu, et al.
Published: (2017-12-01)

Olmesartan inhibits cultured rat aortic smooth muscle cell death induced by cyclic mechanical stretch through the inhibition of the c-Jun N-terminal kinase and p38 signaling pathways
by: Satoyasu Ito, et al.
Published: (2015-01-01)

Kinase Signaling in Apoptosis Induced by Saturated Fatty Acids in Pancreatic β-Cells
by: Jan Šrámek, et al.
Published: (2016-09-01)

Ivabradine Ameliorates Cardiac Diastolic Dysfunction in Diabetic Mice Independent of Heart Rate Reduction
by: Hao Xie, et al.
Published: (2021-06-01)

Activation of c-Jun N-terminal Kinase, a Potential Therapeutic Target in Autoimmune Arthritis
by: Benjamin Lai, et al.
Published: (2020-11-01)

Oxidative Versus Thrombotic Stimulation of Platelets Differentially activates Signalling Pathways
by: Pouran Karimi, et al.
Published: (2013-07-01)

Stress-Activated Protein Kinases in Spinal Cord Injury: Focus on Roles of p38
by: Yoshitoshi Kasuya, et al.
Published: (2018-03-01)

Mitogen-Activated Protein Kinase Pathway in Amyotrophic Lateral Sclerosis
by: TG Sahana, et al.
Published: (2021-08-01)

Mesoporous silica SBA-15 decreases hyperammonemia and affects the gene expression of mitogen-activated protein kinases in the prefrontal cortex of rats with bile duct ligation
by: Shamseddin Ahmadi, et al.
Published: (2020-10-01)

Retrochalcone Echinatin Triggers Apoptosis of Esophageal Squamous Cell Carcinoma via ROS- and ER Stress-Mediated Signaling Pathways
by: Ah-Won Kwak, et al.
Published: (2019-11-01)

Roles of the MST1-JNK signaling pathway in apoptosis of colorectal cancer cells induced by Taurine
by: Zhuoqi Liu, et al.
Published: (2018-01-01)

Cloning and Functional Characterization of c-Jun NH2-Terminal Kinase from the Mediterranean Species of the Whitefly Bemisia tabaci Complex
by: Xiao-Wei Wang, et al.
Published: (2013-06-01)

Neuroprotective effects of Activin A on endoplasmic reticulum stress-mediated apoptotic and autophagic PC12 cell death
by: Long-xing Xue, et al.
Published: (2017-01-01)

The JNK Signaling Pathway in Renal Fibrosis
by: Keren Grynberg, et al.
Published: (2017-10-01)

Pro-apoptotic and pro-proliferation functions of the JNK pathway of Drosophila: roles in cell competition, tumorigenesis and regeneration
by: Noelia Pinal, et al.
Published: (2019-03-01)

Inhibition of Casein Kinase 2 Protects Oligodendrocytes From Excitotoxicity by Attenuating JNK/p53 Signaling Cascade
by: Manuel Canedo-Antelo, et al.
Published: (2018-09-01)

Involvement of JNK and Caspase Activation in Hoiamide A-Induced Neurotoxicity in Neocortical Neurons
by: Zhengyu Cao, et al.
Published: (2015-02-01)

Activation of JNK/c-Jun is required for the proliferation, survival, and angiogenesis induced by EET in pulmonary artery endothelial cells[S]
by: Jun Ma, et al.
Published: (2012-06-01)

Mycosporine-Like Amino Acids Promote Wound Healing through Focal Adhesion Kinase (FAK) and Mitogen-Activated Protein Kinases (MAP Kinases) Signaling Pathway in Keratinocytes
by: Yun-Hee Choi, et al.
Published: (2015-11-01)

The Unresolved Pathophysiology of Lymphedema
by: Syaza Hazwany Azhar, et al.
Published: (2020-03-01)

Molecular Characterization and Expression of OfJNK and Ofp38 in Ostrinia furnacalis (Guenée) Under Different Environmental Stressors
by: Li Su, et al.
Published: (2020-02-01)

Tricetin Induces Apoptosis of Human Leukemic HL-60 Cells through a Reactive Oxygen Species-Mediated c-Jun N-Terminal Kinase Activation Pathway
by: Ming-Hsien Chien, et al.
Published: (2017-07-01)

Acrolein-induced activation of mitogen-activated protein kinase signaling is mediated by alkylation of thioredoxin reductase and thioredoxin 1
by: Matthew J. Randall, et al.
Published: (2013-01-01)

Increased expression of p38 mitogen- activated protein kinase is related to the acute renal lesions induced by gentamicin
by: Volpini R.A., et al.
Published: (2006-01-01)

MCP-1 Stimulates MMP-9 Expression via ERK 1/2 and p38 MAPK Signaling Pathways in Human Aortic Smooth Muscle Cells
by: Ci-Qiu Yang, et al.
Published: (2014-07-01)

Semaphorin3A-Inhibitor Ameliorates Doxorubicin-Induced Podocyte Injury
by: Yizhen Sang, et al.
Published: (2020-06-01)

Antinociceptive Effect of Najanalgesin from Naja Naja Atra in a Neuropathic Pain Model via Inhibition of c-Jun NH2-terminal Kinase
by: Ying-Xia Liang, et al.
Published: (2015-01-01)

Thapsigargin induces apoptosis in adrenocortical carcinoma by activating endoplasmic reticulum stress and the JNK signaling pathway: an in vitro and in vivo study
by: Wu L, et al.
Published: (2019-08-01)

Compound K, a Metabolite of Ginseng Saponin, Induces Mitochondria-Dependent and Caspase-Dependent Apoptosis via the Generation of Reactive Oxygen Species in Human Colon Cancer Cells
by: Jin Won Hyun, et al.
Published: (2010-12-01)

c-Jun N-Terminal Kinase Inhibitors as Potential Leads for New Therapeutics for Alzheimer’s Diseases
by: Stephanie Cristine Hepp Rehfeldt, et al.
Published: (2020-12-01)

Therapeutic Effects of Tryptanthrin and Tryptanthrin-6-Oxime in Models of Rheumatoid Arthritis
by: Liliya N. Kirpotina, et al.
Published: (2020-07-01)

Role of c-Jun N-terminal Kinase (JNK) in Obesity and Type 2 Diabetes
by: Justin Hou Ming Yung, et al.
Published: (2020-03-01)

JNK and p38 Inhibitors Prevent Transforming Growth Factor-β1-Induced Myofibroblast Transdifferentiation in Human Graves’ Orbital Fibroblasts
by: Tzu-Yu Hou, et al.
Published: (2021-03-01)

Fish c-Jun N-Terminal Kinase (JNK) Pathway Is Involved in Bacterial MDP-Induced Intestinal Inflammation
by: Fufa Qu, et al.
Published: (2020-03-01)

Understanding MAPK Signaling Pathways in Apoptosis
by: Jicheng Yue, et al.
Published: (2020-03-01)

Saponins from Panax japonicus attenuate age-related neuroinflammation via regulation of the mitogen-activated protein kinase and nuclear factor kappa B signaling pathways
by: Li-li Deng, et al.
Published: (2017-01-01)

C-Jun N-terminal kinase inhibitors: Structural insight into kinase-inhibitor complexes
by: Men Thi Hoai Duong, et al.
Published: (2020-01-01)