Enhancing the Efficacy of Metal‐Free MRI Contrast Agents via Conjugating Nitroxides onto PEGylated Cross‐Linked Poly(Carboxylate Ester)

Enhancing the Efficacy of Metal‐Free MRI Contrast Agents via Conjugating Nitroxides onto PEGylated Cross‐Linked Poly(Carboxylate Ester)

Abstract Herein, two water‐soluble PROXYL‐based magnetic resonance imaging (MRI) macromolecular organic contrast agents (mORCAs) are designed and synthesized: linear and cross‐linked PCE‐mPEG‐Ppa‐PROXYL. They are prepared by conjugating linear and cross‐linked poly(carboxylate ester) (PCE) with poly...

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Bibliographic Details
Main Authors:	Shiwei Guo, Xiaoming Wang, Yan Dai, Xinghang Dai, Zhiqian Li, Qiang Luo, Xiuli Zheng, Zhongwei Gu, Hu Zhang, Qiyong Gong, Kui Luo
Format:	Article
Language:	English
Published:	Wiley 2020-07-01
Series:	Advanced Science
Subjects:	branched polymers magnetic resonance imaging metal‐free contrast agents nitroxides poly(carboxylate ester)
Online Access:	https://doi.org/10.1002/advs.202000467

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