RAC3 influences the chemoresistance of colon cancer cells through autophagy and apoptosis inhibition

RAC3 influences the chemoresistance of colon cancer cells through autophagy and apoptosis inhibition

Abstract Background RAC3 coactivator overexpression has been implicated in tumorigenesis, contributing to inhibition of apoptosis and autophagy. Both mechanisms are involved in resistance to treatment with chemotherapeutic agents. The aim of this study was to investigate its role in chemoresistance...

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Bibliographic Details
Main Authors: María Fernanda Rubio, María Cecilia Lira, Francisco Damián Rosa, Adrían Dario Sambresqui, María Cecilia Salazar Güemes, Mónica Alejandra Costas
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Cancer Cell International
Subjects:
Colorectal cancer
RAC3
Chemoresistance
Apoptosis
Autophagy
Online Access:http://link.springer.com/article/10.1186/s12935-017-0483-x

Internet

http://link.springer.com/article/10.1186/s12935-017-0483-x

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