Targeted Suppression and Knockout of ASCT2 or LAT1 in Epithelial and Mesenchymal Human Liver Cancer Cells Fail to Inhibit Growth

Targeted Suppression and Knockout of ASCT2 or LAT1 in Epithelial and Mesenchymal Human Liver Cancer Cells Fail to Inhibit Growth

Amino acid transporters alanine-serine-cysteine transporter 2 (ASCT2) and L-Type Amino Acid Transporter 1 (LAT1) are coordinately enhanced in human cancers where among other roles, they are thought to drive mechanistic target-of-rapamycin (mTOR) growth signaling. To assess ASCT2 and LAT1 as therapeu...

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Bibliographic Details
Main Authors: Paige J. Bothwell, Clare D. Kron, Evan F. Wittke, Bradley N. Czerniak, Barrie P. Bode
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:International Journal of Molecular Sciences
Subjects:
ASCT2
SLC1A5
LAT1
SLC7A5
hepatocellular carcinoma
CRISPR-Cas9
shRNA
amino acid transport
mTOR
Online Access:http://www.mdpi.com/1422-0067/19/7/2093

Internet

http://www.mdpi.com/1422-0067/19/7/2093

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