Pilot Study of CYP2B6 Genetic Variation to Explore the Contribution of Nitrosamine Activation to Lung Carcinogenesis

Pilot Study of CYP2B6 Genetic Variation to Explore the Contribution of Nitrosamine Activation to Lung Carcinogenesis

We explored the contribution of nitrosamine metabolism to lung cancer in a pilot investigation of genetic variation in CYP2B6, a high-affinity enzymatic activator of tobacco-specific nitrosamines with a negligible role in nicotine metabolism. Previously we found that variation in CYP2A6 and CHRNA5-C...

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Bibliographic Details
Main Authors: Rachel F. Tyndale, Margaret R. Spitz, Christopher I. Amos, Catherine A. Wassenaar, Qiong Dong
Format: Article
Language:English
Published: MDPI AG 2013-04-01
Series:International Journal of Molecular Sciences
Subjects:
CYP2B6
CYP2A6
CHRNA5-CHRNA3-CHRNB4
tobacco specific nitrosamines
lung cancer risk
genetic variation
Online Access:http://www.mdpi.com/1422-0067/14/4/8381

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