Antihyperglycemic and neuroprotective effects of Wattakaka volubilis (L.f.) Stapf root against streptozotocin induced diabetes
ABSTRACT Murva is an important drug in Ayurveda. Wattakaka volubilis is used as one of the botanical sources of Murva. The aim of this study is to evaluate the effect of the alcohol extract of W. volubilis root in streptoztocin (STZ) induced diabetes and diabetic neuropathy. Diabetes mellitus (DM) w...
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doaj-61dbe5d16ad540d2a583c08e2e8e1c9f2020-11-24T23:12:25ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-979052341342410.1590/s1984-82502016000300007S1984-82502016000300413Antihyperglycemic and neuroprotective effects of Wattakaka volubilis (L.f.) Stapf root against streptozotocin induced diabetesHajira Banu HaroonAnita MuraliABSTRACT Murva is an important drug in Ayurveda. Wattakaka volubilis is used as one of the botanical sources of Murva. The aim of this study is to evaluate the effect of the alcohol extract of W. volubilis root in streptoztocin (STZ) induced diabetes and diabetic neuropathy. Diabetes mellitus (DM) was induced by the administration of STZ (45 mg/kg, i.p). DM was induced within 72 h. Diabetic animals were treated with glimepiride (0.5 mg/kg) and ethyl alcohol extract 100 and 200 mg/kg for 21 d. After determining the changes in fasting serum glucose and lipid profile, animals were further treated for a period of 15 d to determine the protective effect of extract against diabetic neuropathy. All the alcohol extract treated animals, showed a significant decrease in serum glucose level (P<0.001), and overall decrease in the severity of diabetic neuropathy. Alcohol extract of W. volubilis root showed antihyperglycemic activity and beneficial protection against diabetic neuropathy and hence can be a promising agent for treatment and prevention of diabetic neuropathy.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000300413&lng=en&tlng=enDiabetes mellitus/studyDiabetic neuropathiesWattakaka volubilis (L.f.) Stapf/ root/induced diabetes |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hajira Banu Haroon Anita Murali |
spellingShingle |
Hajira Banu Haroon Anita Murali Antihyperglycemic and neuroprotective effects of Wattakaka volubilis (L.f.) Stapf root against streptozotocin induced diabetes Brazilian Journal of Pharmaceutical Sciences Diabetes mellitus/study Diabetic neuropathies Wattakaka volubilis (L.f.) Stapf/ root/induced diabetes |
author_facet |
Hajira Banu Haroon Anita Murali |
author_sort |
Hajira Banu Haroon |
title |
Antihyperglycemic and neuroprotective effects of Wattakaka volubilis (L.f.) Stapf root against streptozotocin induced diabetes |
title_short |
Antihyperglycemic and neuroprotective effects of Wattakaka volubilis (L.f.) Stapf root against streptozotocin induced diabetes |
title_full |
Antihyperglycemic and neuroprotective effects of Wattakaka volubilis (L.f.) Stapf root against streptozotocin induced diabetes |
title_fullStr |
Antihyperglycemic and neuroprotective effects of Wattakaka volubilis (L.f.) Stapf root against streptozotocin induced diabetes |
title_full_unstemmed |
Antihyperglycemic and neuroprotective effects of Wattakaka volubilis (L.f.) Stapf root against streptozotocin induced diabetes |
title_sort |
antihyperglycemic and neuroprotective effects of wattakaka volubilis (l.f.) stapf root against streptozotocin induced diabetes |
publisher |
Universidade de São Paulo |
series |
Brazilian Journal of Pharmaceutical Sciences |
issn |
2175-9790 |
description |
ABSTRACT Murva is an important drug in Ayurveda. Wattakaka volubilis is used as one of the botanical sources of Murva. The aim of this study is to evaluate the effect of the alcohol extract of W. volubilis root in streptoztocin (STZ) induced diabetes and diabetic neuropathy. Diabetes mellitus (DM) was induced by the administration of STZ (45 mg/kg, i.p). DM was induced within 72 h. Diabetic animals were treated with glimepiride (0.5 mg/kg) and ethyl alcohol extract 100 and 200 mg/kg for 21 d. After determining the changes in fasting serum glucose and lipid profile, animals were further treated for a period of 15 d to determine the protective effect of extract against diabetic neuropathy. All the alcohol extract treated animals, showed a significant decrease in serum glucose level (P<0.001), and overall decrease in the severity of diabetic neuropathy. Alcohol extract of W. volubilis root showed antihyperglycemic activity and beneficial protection against diabetic neuropathy and hence can be a promising agent for treatment and prevention of diabetic neuropathy. |
topic |
Diabetes mellitus/study Diabetic neuropathies Wattakaka volubilis (L.f.) Stapf/ root/induced diabetes |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000300413&lng=en&tlng=en |
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