Antihyperglycemic and neuroprotective effects of Wattakaka volubilis (L.f.) Stapf root against streptozotocin induced diabetes

ABSTRACT Murva is an important drug in Ayurveda. Wattakaka volubilis is used as one of the botanical sources of Murva. The aim of this study is to evaluate the effect of the alcohol extract of W. volubilis root in streptoztocin (STZ) induced diabetes and diabetic neuropathy. Diabetes mellitus (DM) w...

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Main Authors: Hajira Banu Haroon, Anita Murali
Format: Article
Language:English
Published: Universidade de São Paulo
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000300413&lng=en&tlng=en
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spelling doaj-61dbe5d16ad540d2a583c08e2e8e1c9f2020-11-24T23:12:25ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-979052341342410.1590/s1984-82502016000300007S1984-82502016000300413Antihyperglycemic and neuroprotective effects of Wattakaka volubilis (L.f.) Stapf root against streptozotocin induced diabetesHajira Banu HaroonAnita MuraliABSTRACT Murva is an important drug in Ayurveda. Wattakaka volubilis is used as one of the botanical sources of Murva. The aim of this study is to evaluate the effect of the alcohol extract of W. volubilis root in streptoztocin (STZ) induced diabetes and diabetic neuropathy. Diabetes mellitus (DM) was induced by the administration of STZ (45 mg/kg, i.p). DM was induced within 72 h. Diabetic animals were treated with glimepiride (0.5 mg/kg) and ethyl alcohol extract 100 and 200 mg/kg for 21 d. After determining the changes in fasting serum glucose and lipid profile, animals were further treated for a period of 15 d to determine the protective effect of extract against diabetic neuropathy. All the alcohol extract treated animals, showed a significant decrease in serum glucose level (P<0.001), and overall decrease in the severity of diabetic neuropathy. Alcohol extract of W. volubilis root showed antihyperglycemic activity and beneficial protection against diabetic neuropathy and hence can be a promising agent for treatment and prevention of diabetic neuropathy.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000300413&lng=en&tlng=enDiabetes mellitus/studyDiabetic neuropathiesWattakaka volubilis (L.f.) Stapf/ root/induced diabetes
collection DOAJ
language English
format Article
sources DOAJ
author Hajira Banu Haroon
Anita Murali
spellingShingle Hajira Banu Haroon
Anita Murali
Antihyperglycemic and neuroprotective effects of Wattakaka volubilis (L.f.) Stapf root against streptozotocin induced diabetes
Brazilian Journal of Pharmaceutical Sciences
Diabetes mellitus/study
Diabetic neuropathies
Wattakaka volubilis (L.f.) Stapf/ root/induced diabetes
author_facet Hajira Banu Haroon
Anita Murali
author_sort Hajira Banu Haroon
title Antihyperglycemic and neuroprotective effects of Wattakaka volubilis (L.f.) Stapf root against streptozotocin induced diabetes
title_short Antihyperglycemic and neuroprotective effects of Wattakaka volubilis (L.f.) Stapf root against streptozotocin induced diabetes
title_full Antihyperglycemic and neuroprotective effects of Wattakaka volubilis (L.f.) Stapf root against streptozotocin induced diabetes
title_fullStr Antihyperglycemic and neuroprotective effects of Wattakaka volubilis (L.f.) Stapf root against streptozotocin induced diabetes
title_full_unstemmed Antihyperglycemic and neuroprotective effects of Wattakaka volubilis (L.f.) Stapf root against streptozotocin induced diabetes
title_sort antihyperglycemic and neuroprotective effects of wattakaka volubilis (l.f.) stapf root against streptozotocin induced diabetes
publisher Universidade de São Paulo
series Brazilian Journal of Pharmaceutical Sciences
issn 2175-9790
description ABSTRACT Murva is an important drug in Ayurveda. Wattakaka volubilis is used as one of the botanical sources of Murva. The aim of this study is to evaluate the effect of the alcohol extract of W. volubilis root in streptoztocin (STZ) induced diabetes and diabetic neuropathy. Diabetes mellitus (DM) was induced by the administration of STZ (45 mg/kg, i.p). DM was induced within 72 h. Diabetic animals were treated with glimepiride (0.5 mg/kg) and ethyl alcohol extract 100 and 200 mg/kg for 21 d. After determining the changes in fasting serum glucose and lipid profile, animals were further treated for a period of 15 d to determine the protective effect of extract against diabetic neuropathy. All the alcohol extract treated animals, showed a significant decrease in serum glucose level (P<0.001), and overall decrease in the severity of diabetic neuropathy. Alcohol extract of W. volubilis root showed antihyperglycemic activity and beneficial protection against diabetic neuropathy and hence can be a promising agent for treatment and prevention of diabetic neuropathy.
topic Diabetes mellitus/study
Diabetic neuropathies
Wattakaka volubilis (L.f.) Stapf/ root/induced diabetes
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000300413&lng=en&tlng=en
work_keys_str_mv AT hajirabanuharoon antihyperglycemicandneuroprotectiveeffectsofwattakakavolubilislfstapfrootagainststreptozotocininduceddiabetes
AT anitamurali antihyperglycemicandneuroprotectiveeffectsofwattakakavolubilislfstapfrootagainststreptozotocininduceddiabetes
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