NOTCH2 negatively regulates metastasis and epithelial-Mesenchymal transition via TRAF6/AKT in nasopharyngeal carcinoma

NOTCH2 negatively regulates metastasis and epithelial-Mesenchymal transition via TRAF6/AKT in nasopharyngeal carcinoma

Abstract Background Clinically, distant metastasis after primary treatment remains a key problem in nasopharyngeal carcinoma (NPC). Thus, identification of the underlying mechanisms and development of novel therapeutic strategies are urgently needed. NOTCH has been shown to function as a tumor promo...

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Bibliographic Details
Main Authors: You Zou, Rui Yang, Mao-Ling Huang, Yong-Gang Kong, Jian-Fei Sheng, Ze-Zhang Tao, Ling Gao, Shi-Ming Chen
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
NOTCH2
Nasopharyngeal carcinoma
Metastasis
EMT
NOTCH2/TRAF6/AKT axis
Online Access:http://link.springer.com/article/10.1186/s13046-019-1463-x

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