Neutralising effects of small molecule toxin inhibitors on nanofractionated coagulopathic Crotalinae snake venoms

Neutralising effects of small molecule toxin inhibitors on nanofractionated coagulopathic Crotalinae snake venoms

Repurposing small molecule drugs and drug candidates is considered as a promising approach to revolutionise the treatment of snakebite envenoming. In this study, we investigated the inhibiting effects of the small molecules varespladib (nonspecific phospholipase A2 inhibitor), marimastat (broad spec...

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Bibliographic Details
Main Authors: Chunfang Xie, Julien Slagboom, Laura-Oana Albulescu, Govert W. Somsen, Freek J. Vonk, Nicholas R. Casewell, Jeroen Kool
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Snakebite
Antivenom
Varespladib
Marimastat
Dimercaprol
Chelators
Online Access:http://www.sciencedirect.com/science/article/pii/S221138352030705X

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http://www.sciencedirect.com/science/article/pii/S221138352030705X

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