The inhibition of Nrf2 accelerates renal lipid deposition through suppressing the ACSL1 expression in obesity-related nephropathy

The inhibition of Nrf2 accelerates renal lipid deposition through suppressing the ACSL1 expression in obesity-related nephropathy

Background: Obesity has become a worldwide epidemic, and the incidence of obesity is increasing year by year. Obesity-related nephropathy (ORN) is a common kidney complication of obesity. Long-chain acyl-CoA synthetases-1, (ACSL1), is a key enzyme in the oxidative metabolism of fatty acids in mitoch...

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Bibliographic Details
Main Authors: Yinyin Chen, Liyu He, Yiya Yang, Ying Chen, Yanran Song, Xi Lu, Yumei Liang
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Renal Failure
Subjects:
nrf2
oxidative stress
lipid deposition
acsl1
obesity-related nephropathy
Online Access:http://dx.doi.org/10.1080/0886022X.2019.1655450

Internet

http://dx.doi.org/10.1080/0886022X.2019.1655450

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