Infiltration of plasma cells in colorectal adenocarcinoma associated with autoimmune encephalitis

Infiltration of plasma cells in colorectal adenocarcinoma associated with autoimmune encephalitis

Abstract Paraneoplastic autoimmune encephalitis (PAE) represents a group of rare neurological syndromes associated with neoplastic diseases. Here, we report a case that multiple anti‐neuronal antibodies were present in a patient with PAE who developed both small cell lung cancer and colorectal adeno...

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Bibliographic Details
Main Authors: Yaqing Shu, Dan He, Xiaoyu Ma, Jianfang Li, Haotian Wu, Chen Chen, Zhengqi Lu, Frank Petersen, Wei Qiu, Xinhua Yu
Format: Article
Language:English
Published: Wiley 2021-02-01
Series:Annals of Clinical and Translational Neurology
Online Access:https://doi.org/10.1002/acn3.51283
Description
Summary:Abstract Paraneoplastic autoimmune encephalitis (PAE) represents a group of rare neurological syndromes associated with neoplastic diseases. Here, we report a case that multiple anti‐neuronal antibodies were present in a patient with PAE who developed both small cell lung cancer and colorectal adenocarcinoma. Furthermore, the immunopathological investigation of the colorectal adenocarcinoma revealed the formation of abnormal neuronal antigens and a massive infiltration of plasma cells in the tumor tissue. These findings support the hypothesis that expression of neuronal antigens in neoplasm initiates autoimmune responses in PAE.
ISSN:2328-9503

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