Efficacy of tocilizumab therapy in a patient with severe pancytopenia associated with a STAT3 gain-of-function mutation

Efficacy of tocilizumab therapy in a patient with severe pancytopenia associated with a STAT3 gain-of-function mutation

Abstract Background We aimed to report the clinical characteristics, immunological features, and treatment of one patient with a de novo STAT3 gain-of-function mutation identified by next generation sequencing. We investigated the efficacy of tocilizumab therapy in immune dysregulation diseases caus...

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Bibliographic Details
Main Authors: Wenjie Wang, Luyao Liu, Xiaoying Hui, Ying Wang, Wenjing Ying, Qinhua Zhou, Jia Hou, Mi Yang, Bijun Sun, Jinqiao Sun, Xiaochuan Wang
Format: Article
Language:English
Published: BMC 2021-03-01
Series:BMC Immunology
Subjects:
STAT3 transcription factor
Tocilizumab
Immune Dysregulation
Gain-of-function mutations
Online Access:https://doi.org/10.1186/s12865-021-00411-1

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