The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance

How Akt pathway is activated under stress is poorly understood. Here, the authors demonstrate the crucial role of AMPK for cellular stresses and growth factors- mediated Akt activation through a mechanism involving the E3 ubiquitin ligase Skp2 and Cullin-1.

Bibliographic Details
Main Authors:	Fei Han, Chien-Feng Li, Zhen Cai, Xian Zhang, Guoxiang Jin, Wei-Na Zhang, Chuan Xu, Chi-Yun Wang, John Morrow, Shuxing Zhang, Dazhi Xu, Guihua Wang, Hui-Kuan Lin
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-11-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-07188-9

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spelling	doaj-61bf2407c8eb4a9eb5d46d59f18432bf2021-05-11T09:55:55ZengNature Publishing GroupNature Communications2041-17232018-11-019111610.1038/s41467-018-07188-9The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistanceFei Han0Chien-Feng Li1Zhen Cai2Xian Zhang3Guoxiang Jin4Wei-Na Zhang5Chuan Xu6Chi-Yun Wang7John Morrow8Shuxing Zhang9Dazhi Xu10Guihua Wang11Hui-Kuan Lin12Department of Cancer Biology, Wake Forest School of MedicineDepartment of Pathology, Chi-Mei Foundational Medical CenterDepartment of Cancer Biology, Wake Forest School of MedicineDepartment of Cancer Biology, Wake Forest School of MedicineDepartment of Cancer Biology, Wake Forest School of MedicineDepartment of Cancer Biology, Wake Forest School of MedicineDepartment of Cancer Biology, Wake Forest School of MedicineDepartment of Cancer Biology, Wake Forest School of MedicineDepartment of Experimental Therapeutics, The University of Texas MD Anderson Cancer CenterDepartment of Experimental Therapeutics, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Cancer Biology, Wake Forest School of MedicineDepartment of Cancer Biology, Wake Forest School of MedicineHow Akt pathway is activated under stress is poorly understood. Here, the authors demonstrate the crucial role of AMPK for cellular stresses and growth factors- mediated Akt activation through a mechanism involving the E3 ubiquitin ligase Skp2 and Cullin-1.https://doi.org/10.1038/s41467-018-07188-9
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Fei Han Chien-Feng Li Zhen Cai Xian Zhang Guoxiang Jin Wei-Na Zhang Chuan Xu Chi-Yun Wang John Morrow Shuxing Zhang Dazhi Xu Guihua Wang Hui-Kuan Lin
spellingShingle	Fei Han Chien-Feng Li Zhen Cai Xian Zhang Guoxiang Jin Wei-Na Zhang Chuan Xu Chi-Yun Wang John Morrow Shuxing Zhang Dazhi Xu Guihua Wang Hui-Kuan Lin The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance Nature Communications
author_facet	Fei Han Chien-Feng Li Zhen Cai Xian Zhang Guoxiang Jin Wei-Na Zhang Chuan Xu Chi-Yun Wang John Morrow Shuxing Zhang Dazhi Xu Guihua Wang Hui-Kuan Lin
author_sort	Fei Han
title	The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance
title_short	The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance
title_full	The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance
title_fullStr	The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance
title_full_unstemmed	The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance
title_sort	critical role of ampk in driving akt activation under stress, tumorigenesis and drug resistance
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-11-01
description	How Akt pathway is activated under stress is poorly understood. Here, the authors demonstrate the crucial role of AMPK for cellular stresses and growth factors- mediated Akt activation through a mechanism involving the E3 ubiquitin ligase Skp2 and Cullin-1.
url	https://doi.org/10.1038/s41467-018-07188-9
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The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance

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