A Simple Oligonucleotide Biochip Capable of Rapidly Detecting Known Mitochondrial DNA Mutations in Chinese Patients with Leber’S Hereditary Optic Neuropathy (LHON)

A Simple Oligonucleotide Biochip Capable of Rapidly Detecting Known Mitochondrial DNA Mutations in Chinese Patients with Leber’S Hereditary Optic Neuropathy (LHON)

Leber's hereditary optic neuropathy (LHON) is a maternally transmitted disease. Clinically, no efficient assay protocols have been available. In this study, we aimed to develop an oligonucleotide biochip specialized for detection of known base substitution mutations in mitochondrial DNA causing...

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Bibliographic Details
Main Authors: Wei-Dong Du, Gang Chen, Hui-Min Cao, Qing-Hui Jin, Rong-Feng Liao, Xiang-Cheng He, Da-Ben Chen, Shu-Ren Huang, Hui Zhao, Yong-Mei Lv, Hua-Yang Tang, Xian-Fa Tang, Yong-Qing Wang, Song Sun, Jian-Long Zhao, Xue-Jun Zhang
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:Disease Markers
Online Access:http://dx.doi.org/10.3233/DMA-2011-0767

Internet

http://dx.doi.org/10.3233/DMA-2011-0767

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