A cis‐eQTL genetic variant in PLK4 confers high risk of hepatocellular carcinoma

A cis‐eQTL genetic variant in PLK4 confers high risk of hepatocellular carcinoma

Abstract Purpose The overexpression and knockdown of PLK4 were both reported to generate aneuploidy. Thus, we aimed to investigate whether genetic variants in PLK4 contribute to the development of hepatocellular carcinoma (HCC). Methods We evaluated associations of common variants in PLK4 and its pr...

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Bibliographic Details
Main Authors: Lijuan Meng, Yan Zhou, Sihan Ju, Jing Han, Ci Song, Jing Kong, Yifei Wu, Shuai Lu, Jiani Xu, Wenwen Yuan, Erbao Zhang, Cheng Wang, Zhibin Hu, Yayun Gu, Rongcheng Luo, Xuehao Wang
Format: Article
Language:English
Published: Wiley 2019-10-01
Series:Cancer Medicine
Subjects:
aneuploidy
cancer‐testis gene
CFI‐400945
hepatocellular carcinoma
PLK4
Online Access:https://doi.org/10.1002/cam4.2487

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