Deuterium depletion induces anxiolytic-like effects in rats
Deuterium-depleted water (DDW) has a concentration of deuterium 6-7 times lower than naturally occurring water (20-25 ppm vs. 150 ppm). When administered for a longer period, it can reduce the concentration of deuterium throughout the body, activating cellular mechanisms that depend on p...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
University of Belgrade, University of Novi Sad
2014-01-01
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| Series: | Archives of Biological Sciences |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0354-4664/2014/0354-46641402947M.pdf |
| Summary: | Deuterium-depleted water (DDW) has a concentration of deuterium 6-7 times
lower than naturally occurring water (20-25 ppm vs. 150 ppm). When
administered for a longer period, it can reduce the concentration of
deuterium throughout the body, activating cellular mechanisms that depend on
protons. The aim of the present work was to investigate the influence of
chronic DDW administration on anxiety-related processes in Wistar rats when
compared to a control group that received distilled water, as studied in an
elevated plus maze behavioral test. Our results describe a possible
anxiolytic-like effect of DDW administration on rats, as shown by the
increase in the percentage of time and number of entries in the open arms of
the elevated plus maze. The administration of DDW also resulted in stimulated
head-dipping behavior in the open arms, which is a behavioral change that
characterizes the exploratory behavior and decreased inhibition/ fear in an
unfamiliar environment. We conclude that the change in this balance may have
important consequences for many biological mechanisms. A deuterium
desaturation treatment with DDW might have a use in anxiety disorders. |
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| ISSN: | 0354-4664 1821-4339 |