Mesenchymal stem cell-derived interleukin-28 drives the selection of apoptosis resistant bone metastatic prostate cancer

The effects of bone-marrow derived MSCs on prostate cancer cells remain unknown. Here the authors show that MSC-derived IL-28 induces prostate cancer cell apoptosis via IL-28Rα-STAT1 signalling, while acquired resistance to apoptosis is associated with a shift in IL-28Rα signalling via STAT1 to STAT...

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Main Authors:	Jeremy J. McGuire, Jeremy S. Frieling, Chen Hao Lo, Tao Li, Ayaz Muhammad, Harshani R. Lawrence, Nicholas J. Lawrence, Leah M. Cook, Conor C. Lynch
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-20962-6

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spelling	doaj-61b815bbfbe3485cb1696124b372aa502021-02-07T12:13:29ZengNature Publishing GroupNature Communications2041-17232021-02-0112111310.1038/s41467-021-20962-6Mesenchymal stem cell-derived interleukin-28 drives the selection of apoptosis resistant bone metastatic prostate cancerJeremy J. McGuire0Jeremy S. Frieling1Chen Hao Lo2Tao Li3Ayaz Muhammad4Harshani R. Lawrence5Nicholas J. Lawrence6Leah M. Cook7Conor C. Lynch8Cancer Biology Ph.D. Program, University of South FloridaTumor Biology Department, H. Lee Moffitt Cancer Center and Research InstituteCancer Biology Ph.D. Program, University of South FloridaTumor Biology Department, H. Lee Moffitt Cancer Center and Research InstituteDepartment of Drug Discovery, H. Lee Moffitt Cancer Center and Research InstituteDepartment of Drug Discovery, H. Lee Moffitt Cancer Center and Research InstituteDepartment of Drug Discovery, H. Lee Moffitt Cancer Center and Research InstituteDepartment of Pathology and Microbiology, University of Nebraska Medical CenterTumor Biology Department, H. Lee Moffitt Cancer Center and Research InstituteThe effects of bone-marrow derived MSCs on prostate cancer cells remain unknown. Here the authors show that MSC-derived IL-28 induces prostate cancer cell apoptosis via IL-28Rα-STAT1 signalling, while acquired resistance to apoptosis is associated with a shift in IL-28Rα signalling via STAT1 to STAT3.https://doi.org/10.1038/s41467-021-20962-6
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jeremy J. McGuire Jeremy S. Frieling Chen Hao Lo Tao Li Ayaz Muhammad Harshani R. Lawrence Nicholas J. Lawrence Leah M. Cook Conor C. Lynch
spellingShingle	Jeremy J. McGuire Jeremy S. Frieling Chen Hao Lo Tao Li Ayaz Muhammad Harshani R. Lawrence Nicholas J. Lawrence Leah M. Cook Conor C. Lynch Mesenchymal stem cell-derived interleukin-28 drives the selection of apoptosis resistant bone metastatic prostate cancer Nature Communications
author_facet	Jeremy J. McGuire Jeremy S. Frieling Chen Hao Lo Tao Li Ayaz Muhammad Harshani R. Lawrence Nicholas J. Lawrence Leah M. Cook Conor C. Lynch
author_sort	Jeremy J. McGuire
title	Mesenchymal stem cell-derived interleukin-28 drives the selection of apoptosis resistant bone metastatic prostate cancer
title_short	Mesenchymal stem cell-derived interleukin-28 drives the selection of apoptosis resistant bone metastatic prostate cancer
title_full	Mesenchymal stem cell-derived interleukin-28 drives the selection of apoptosis resistant bone metastatic prostate cancer
title_fullStr	Mesenchymal stem cell-derived interleukin-28 drives the selection of apoptosis resistant bone metastatic prostate cancer
title_full_unstemmed	Mesenchymal stem cell-derived interleukin-28 drives the selection of apoptosis resistant bone metastatic prostate cancer
title_sort	mesenchymal stem cell-derived interleukin-28 drives the selection of apoptosis resistant bone metastatic prostate cancer
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-02-01
description	The effects of bone-marrow derived MSCs on prostate cancer cells remain unknown. Here the authors show that MSC-derived IL-28 induces prostate cancer cell apoptosis via IL-28Rα-STAT1 signalling, while acquired resistance to apoptosis is associated with a shift in IL-28Rα signalling via STAT1 to STAT3.
url	https://doi.org/10.1038/s41467-021-20962-6
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Mesenchymal stem cell-derived interleukin-28 drives the selection of apoptosis resistant bone metastatic prostate cancer

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