Dynamics of ultrastructural changes in the chorioretinal complex of rat eyes induced by high dose of methanol

• Main Author: N. Molchanyuk
• Format: Article
• Language: English
• Published: Taras Shevchenko National University of Kyiv 2016-11-01
• Series: Vìsnik: Kiïvsʹkij Nacìonalʹnij Unìversitet Imenì Tarasa Ševčenka. Bìologìâ
• Subjects: chorioretinal complex, choriocapillaris, retinal pigment epithelium, retinal photoreceptor cells, ultrastructure, methanol
• Online Access: http://biovestnik.com/index.php/biology/article/view/9

The structure of chorioretinal complex (CRC) of rat eyes was studied by electron microscopy: choriocapillaris, retinal pigment epithelium (RPE) and retinal photoreceptor cells after 40 minutes, 1 hour and 10 minutes, on the first 1 st , 3 rd , 7 th and 14 th days after a single intraperitoneal injection of methanol in a dose of 7.0 g/kg of body weight. It was shown that the primary and significant destructive changes in the structures of the studied complex were observed in the RPE cells, which are characterized by alteration of mitochondria and tubules of smooth endoplasmic reticulum, equation of basal folds and local destruction of the apical microvilli. The destructive processes in the cells were growing in the dynamics of CRC structures research. In parallel, the features of compensatory-regenerative processes in these cells were detected.