Newly generated heparanase knock-out mice unravel co-regulation of heparanase and matrix metalloproteinases.

Newly generated heparanase knock-out mice unravel co-regulation of heparanase and matrix metalloproteinases.

Heparanase, a mammalian endo-beta-D-glucuronidase, specifically degrades heparan sulfate proteoglycans ubiquitously associated with the cell surface and extracellular matrix. This single gene encoded enzyme is over-expressed in most human cancers, promoting tumor metastasis and angiogenesis.We repor...

Full description

Bibliographic Details
Main Authors: Eyal Zcharia, Juan Jia, Xiao Zhang, Lea Baraz, Ulf Lindahl, Tamar Peretz, Israel Vlodavsky, Jin-Ping Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2664924?pdf=render

Similar Items

Similar Items