Expansion of an Unusual Virtual Memory CD8+ Subpopulation Bearing Vα3.2 TCR in Themis-Deficient Mice

Expansion of an Unusual Virtual Memory CD8+ Subpopulation Bearing Vα3.2 TCR in Themis-Deficient Mice

Deletion of the gene for Themis affects T cell selection in the thymus, which would be expected to affect the TCR repertoire. We found an increased proportion of cells expressing Vα3.2 (TRAV9N-3) in the peripheral CD8+ T cell population in mice with germline Themis deficiency. Analysis of the TCRα r...

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Bibliographic Details
Main Authors: Mukul Prasad, Lukasz Wojciech, Joanna Brzostek, Jianfang Hu, Yen Leong Chua, Desmond Wai Hon Tung, Jiawei Yap, Vasily Rybakin, Nicholas R. J. Gascoigne
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
bystander activation
CD8 T cell
self-reactive
themis
T cell receptor
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.644483/full

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