Novel Polyketides Produced by the Endophytic Fungus Aspergillus Fumigatus from Cordyceps Sinensis
Five new polyketides, including two pairs of enantiomers and a racemate, were isolated from the fermentation broth of Aspergillus fumigatus, an endophytic fungus isolated from Cordyceps sinensis. Their structures were identified using one-dimensional (1D) and two-dimensional (2D) NMR experiments, an...
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MDPI AG
2018-07-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/23/7/1709 |
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doaj-61ab0bfbd5f54bd2ac33cb36164057792020-11-24T22:10:53ZengMDPI AGMolecules1420-30492018-07-01237170910.3390/molecules23071709molecules23071709Novel Polyketides Produced by the Endophytic Fungus Aspergillus Fumigatus from Cordyceps SinensisDa-Le Guo0Xiao-Hua Li1Dan Feng2Meng-Ying Jin3Yu-Mei Cao4Zhi-Xing Cao5Yu-Cheng Gu6Zhao Geng7Fang Deng8Yun Deng9The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory, Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaThe Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory, Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaThe Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory, Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaThe Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory, Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaThe Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory, Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaThe Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory, Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaSyngenta Jealott’s Hill International Research Centre, Berkshire RG42 6EY, UKSichuan Institute of Food and Drug Control, Chengdu 611731, ChinaThe Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory, Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaThe Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory, Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaFive new polyketides, including two pairs of enantiomers and a racemate, were isolated from the fermentation broth of Aspergillus fumigatus, an endophytic fungus isolated from Cordyceps sinensis. Their structures were identified using one-dimensional (1D) and two-dimensional (2D) NMR experiments, and the absolute configurations of the enantiomers were confirmed using electronic circular dichroism (ECD) calculations. Compounds 1a and 2a exhibited inhibitory activity against the MV4-11 cell line in vitro, with IC50 values of 23.95 µM and 32.70 µM, respectively.http://www.mdpi.com/1420-3049/23/7/1709Aspergillus fumigatusCordyceps sinensisisochromaneschiral resolutionECD calculationcytotoxicity |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Da-Le Guo Xiao-Hua Li Dan Feng Meng-Ying Jin Yu-Mei Cao Zhi-Xing Cao Yu-Cheng Gu Zhao Geng Fang Deng Yun Deng |
| spellingShingle |
Da-Le Guo Xiao-Hua Li Dan Feng Meng-Ying Jin Yu-Mei Cao Zhi-Xing Cao Yu-Cheng Gu Zhao Geng Fang Deng Yun Deng Novel Polyketides Produced by the Endophytic Fungus Aspergillus Fumigatus from Cordyceps Sinensis Molecules Aspergillus fumigatus Cordyceps sinensis isochromanes chiral resolution ECD calculation cytotoxicity |
| author_facet |
Da-Le Guo Xiao-Hua Li Dan Feng Meng-Ying Jin Yu-Mei Cao Zhi-Xing Cao Yu-Cheng Gu Zhao Geng Fang Deng Yun Deng |
| author_sort |
Da-Le Guo |
| title |
Novel Polyketides Produced by the Endophytic Fungus Aspergillus Fumigatus from Cordyceps Sinensis |
| title_short |
Novel Polyketides Produced by the Endophytic Fungus Aspergillus Fumigatus from Cordyceps Sinensis |
| title_full |
Novel Polyketides Produced by the Endophytic Fungus Aspergillus Fumigatus from Cordyceps Sinensis |
| title_fullStr |
Novel Polyketides Produced by the Endophytic Fungus Aspergillus Fumigatus from Cordyceps Sinensis |
| title_full_unstemmed |
Novel Polyketides Produced by the Endophytic Fungus Aspergillus Fumigatus from Cordyceps Sinensis |
| title_sort |
novel polyketides produced by the endophytic fungus aspergillus fumigatus from cordyceps sinensis |
| publisher |
MDPI AG |
| series |
Molecules |
| issn |
1420-3049 |
| publishDate |
2018-07-01 |
| description |
Five new polyketides, including two pairs of enantiomers and a racemate, were isolated from the fermentation broth of Aspergillus fumigatus, an endophytic fungus isolated from Cordyceps sinensis. Their structures were identified using one-dimensional (1D) and two-dimensional (2D) NMR experiments, and the absolute configurations of the enantiomers were confirmed using electronic circular dichroism (ECD) calculations. Compounds 1a and 2a exhibited inhibitory activity against the MV4-11 cell line in vitro, with IC50 values of 23.95 µM and 32.70 µM, respectively. |
| topic |
Aspergillus fumigatus Cordyceps sinensis isochromanes chiral resolution ECD calculation cytotoxicity |
| url |
http://www.mdpi.com/1420-3049/23/7/1709 |
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