Deregulated Expression of SRC, LYN and CKB Kinases by DNA Methylation and Its Potential Role in Gastric Cancer Invasiveness and Metastasis.

Deregulated Expression of SRC, LYN and CKB Kinases by DNA Methylation and Its Potential Role in Gastric Cancer Invasiveness and Metastasis.

Kinases are downstream modulators and effectors of several cellular signaling cascades and play key roles in the development of neoplastic disease. In this study, we aimed to evaluate SRC, LYN and CKB protein and mRNA expression, as well as their promoter methylation, in gastric cancer. We found ele...

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Main Authors: Adriano Azevedo Mello, Mariana Ferreira Leal, Juan Antonio Rey, Giovanny Rebouças Pinto, Leticia Martins Lamarão, Raquel Carvalho Montenegro, Ana Paula Negreiros Nunes Alves, Paulo Pimentel Assumpção, Barbara do Nascimento Borges, Marília Cardoso Smith, Rommel Rodriguez Burbano
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4604160?pdf=render

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