A novel role of snail in regulating tuberin/AMPK pathways to promote renal fibrosis in the new mouse model of type II diabetes

A novel role of snail in regulating tuberin/AMPK pathways to promote renal fibrosis in the new mouse model of type II diabetes

Abstract Epithelial–mesenchymal transition (EMT) plays an important role in tissue fibrosis following chronic exposure to hyperglycemia. This study investigates the role of chronic diabetes in regulating tuberin/snail/AMPK to enhance EMT and increase renal fibrosis. A new mouse model of db/db/TSC2+/...

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Bibliographic Details
Main Authors: Sitai Liang, Mukesh Yadav, Kristine S. Vogel, Samy L. Habib
Format: Article
Language:English
Published: Wiley 2021-09-01
Series:FASEB BioAdvances
Subjects:
AMPK
diabetes
EMT
fibronectin
NFkb
snail
Online Access:https://doi.org/10.1096/fba.2020-00134

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