Síntese e controle de qualidade da ureia enriquecida em 13C para diagnóstico da Helicobacterpylori (HP) Synthesis and quality control of 13C-enriched urea for Helicobacter pylori (HP) diagnosis

• Main Authors: Carlos R. Sant Ana Filho, Claudinéia R. O. Tavares, André V. Ferreira, Clelber V. Prestes, José A. Bendassolli
• Format: Article
• Language: English
• Published: Sociedade Brasileira de Química 2013-01-01
• Series: Química Nova
• Subjects: stable isotope; reactor; enriched compounds
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422013000100020

<abstract language="eng">The aim of the study was to synthesize the urea (13CO(NH2)2), with 99% 13C atoms, and to perform a quality analysis for the diagnosis (breath test) of Helicobacter pylori. Furthermore, the process was submitted to economic analysis. The reaction was performed in a stainless steel reactor, lined with polytetrafluoroethylene, under low pressure and temperature. The synthesis method was shown to be appropriate (2.35 g; 81.9% yield), evidenced by physico-chemical and microbiological results, according to Brazilian legislation. The production and diagnosis costs were competitive compared with national and international market values, rendering this a valuable tool in clinical medicine.