Zika virus infects pericytes in the choroid plexus and enters the central nervous system through the blood-cerebrospinal fluid barrier.

Zika virus (ZIKV) can infect and cause microcephaly and Zika-associated neurological complications in the developing fetal and adult brains. In terms of pathogenesis, a critical question is how ZIKV overcomes the barriers separating the brain from the circulation and gains access to the central nerv...

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Bibliographic Details
Main Authors: Jihye Kim, Brian Alejandro, Michal Hetman, Eyas M Hattab, Joshua Joiner, Horst Schroten, Hiroshi Ishikawa, Dong-Hoon Chung
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-05-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008204