Hepatic Bile Acid Reuptake in the Rat Depends on Bile Acid Conjugation but Not on Agonistic Properties towards FXR and TGR5

Hepatic Bile Acid Reuptake in the Rat Depends on Bile Acid Conjugation but Not on Agonistic Properties towards FXR and TGR5

Farnesoid X receptor (FXR) and Takeda G-protein coupled receptor 5 (TGR5) are the two known bile acid (BA) sensitive receptors and are expressed in the intestine and liver as well as in extra-enterohepatic tissues. The physiological effects of extra-enterohepatic FXR/TRG5 remain unclear. Further, th...

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Bibliographic Details
Main Authors:	Samuel A. J. Trammell, Jens S. Svenningsen, Jens J. Holst, Matthew P. Gillum, Rune E. Kuhre
Format:	Article
Language:	English
Published:	MDPI AG 2020-05-01
Series:	Molecules
Subjects:	hepatic bile acid reuptake bile acid spill over bile acids in plasma portal vein versus periphery FXR and TGR5 receptors
Online Access:	https://www.mdpi.com/1420-3049/25/10/2371

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