Monomorphic post-transplant lymphoproliferative disorder of the tongue: case report and review of literature

• Main Authors: Zimrin Ann, Gocke Christopher D, Burke Allen P, Tavora Fabio, Gonzalez-Cuyar Luis F, Sauk John J, Zhao Xiafeng F
• Format: Article
• Language: English
• Published: BMC 2007-12-01
• Series: Diagnostic Pathology
• Online Access: http://www.diagnosticpathology.org/content/2/1/49

<p>Abstract</p> <p>Background</p> <p>Post-transplant lymphoproliferative disorder (PTLD) is a spectrum of hematological diseases arising in context of immunosuppression after organ transplantation. PTLD can involve any organ; however, it is extremely rare in oral cavity.</p> <p>Methods</p> <p>Using morphologic and immunophenotypic approaches we have studied a case of monomorphic PTLD of the tongue that developed in a patient following unilateral kidney and pancreas transplantation on immunosuppressive therapy. Additionally, cases of PTLD in the oral cavity were reviewed in the English literature.</p> <p>Results</p> <p>The neoplasm showed large cell morphology and B-cell phenotype. In situ hybridization for Epstein-Barr virus was positive. Complete remission was obtained after decreasing immunosuppressive therapy. The patient remained in remission at 790 days' follow up.</p> <p>Conclusion</p> <p>This rare case increased our awareness of PTLD in the oral cavity of patients following solid organ transplantation and immunosuppressive therapy.</p>