Functional identification of close proximity amino acid side chains within the transmembrane-spanning helixes of the P2X2 receptor.

Functional identification of close proximity amino acid side chains within the transmembrane-spanning helixes of the P2X2 receptor.

The transition from the closed to open state greatly alters the intra- and inter-subunit interactions of the P2X receptor (P2XR). The interactions that occur in the transmembrane domain of the P2X2R remain unclear. We used substituted cysteine mutagenesis disulfide mapping to identify pairs of resid...

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Bibliographic Details
Main Authors: Xin Liang, Huijuan Xu, Caiyue Li, Shikui Yin, Tingting Xu, Jinsong Liu, Zhiyuan Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3735612?pdf=render

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