Inhibition of stearoyl-CoA desaturase 1 expression induces CHOP-dependent cell death in human cancer cells.

Inhibition of stearoyl-CoA desaturase 1 expression induces CHOP-dependent cell death in human cancer cells.

BACKGROUND: Cancer cells present a sustained de novo fatty acid synthesis with an increase of saturated and monounsaturated fatty acid (MUFA) production. This change in fatty acid metabolism is associated with overexpression of stearoyl-CoA desaturase 1 (Scd1), which catalyses the transformation of...

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Bibliographic Details
Main Authors: Mélaine Minville-Walz, Anne-Sophie Pierre, Laurent Pichon, Sandrine Bellenger, Cécile Fèvre, Jérôme Bellenger, Christian Tessier, Michel Narce, Mickaël Rialland
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3002938?pdf=render

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