Sinus Bradycardia in Carriers of the SCN5A-1795insD Mutation: Unraveling the Mechanism through Computer Simulations

Sinus Bradycardia in Carriers of the SCN5A-1795insD Mutation: Unraveling the Mechanism through Computer Simulations

The SCN5A gene encodes the pore-forming α-subunit of the ion channel that carries the cardiac fast sodium current (INa). The 1795insD mutation in SCN5A causes sinus bradycardia, with a mean heart rate of 70 beats/min in mutation carriers vs. 77 beats/min in non-carriers from the same family (lowest...

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Bibliographic Details
Main Author: Ronald Wilders
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:International Journal of Molecular Sciences
Subjects:
heart
sinoatrial node
electrophysiology
long-QT syndrome
sinus bradycardia
sick sinus syndrome
genetics
sodium current
ion channels
computer simulations
Online Access:http://www.mdpi.com/1422-0067/19/2/634

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http://www.mdpi.com/1422-0067/19/2/634

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