Transient knockdown of Nucleoside transporter 4 gene expression as a therapeutic target in Leishmania major by antisense RNA: In vitro and in vivo studies

Transient knockdown of Nucleoside transporter 4 gene expression as a therapeutic target in Leishmania major by antisense RNA: In vitro and in vivo studies

Background & objectives: Leishmania parasites cause various clinical symptoms in humans such as cutaneous ulcers and fatal visceral diseases. These parasites cannot synthesize purine rings de novo and must uptake purines from their hosts via salvage. Salvage is regulated by permeases in the cell...

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Bibliographic Details
Main Authors: Farideh Tohidi, Zahra Babaei, Bahram Kazemi, Mojgan Bandehpour, Iraj Sharifi, Mohammad Reza Rabiei, Ebrahim Saedi Dezaki
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2019-01-01
Series:Journal of Vector Borne Diseases
Subjects:
Antisense RNA; gene expression; Leishmania major; Nucleoside transporter 4 gene; transient knockdown
Online Access:http://www.jvbd.org/article.asp?issn=0972-9062;year=2019;volume=56;issue=2;spage=98;epage=104;aulast=Tohidi

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http://www.jvbd.org/article.asp?issn=0972-9062;year=2019;volume=56;issue=2;spage=98;epage=104;aulast=Tohidi

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