Stereotyped initiation of retinal waves by bipolar cells via presynaptic NMDA autoreceptors

Stereotyped initiation of retinal waves by bipolar cells via presynaptic NMDA autoreceptors

Retinal waves are important for visual system development. However, the mechanism involved in their generation remains largely unknown. Here using in vivotwo-photon imaging the authors identify the presence of retinal waves in zebrafish larvae and find that they are initiated at bipolar cells via pr...

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Main Authors: Rong-wei Zhang, Xiao-quan Li, Koichi Kawakami, Jiu-lin Du
Format: Article
Language:English
Published: Nature Publishing Group 2016-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12650
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spelling doaj-614ff8f7d7484ec99b8fa5a89efc0b762021-05-11T11:04:21ZengNature Publishing GroupNature Communications2041-17232016-09-017111210.1038/ncomms12650Stereotyped initiation of retinal waves by bipolar cells via presynaptic NMDA autoreceptorsRong-wei Zhang0Xiao-quan Li1Koichi Kawakami2Jiu-lin Du3Institute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesInstitute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesDivision of Molecular and Developmental Biology, National Institute of GeneticsInstitute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesRetinal waves are important for visual system development. However, the mechanism involved in their generation remains largely unknown. Here using in vivotwo-photon imaging the authors identify the presence of retinal waves in zebrafish larvae and find that they are initiated at bipolar cells via presynaptic NMDARs.https://doi.org/10.1038/ncomms12650
collection DOAJ
language English
format Article
sources DOAJ
author Rong-wei Zhang
Xiao-quan Li
Koichi Kawakami
Jiu-lin Du
spellingShingle Rong-wei Zhang
Xiao-quan Li
Koichi Kawakami
Jiu-lin Du
Stereotyped initiation of retinal waves by bipolar cells via presynaptic NMDA autoreceptors
Nature Communications
author_facet Rong-wei Zhang
Xiao-quan Li
Koichi Kawakami
Jiu-lin Du
author_sort Rong-wei Zhang
title Stereotyped initiation of retinal waves by bipolar cells via presynaptic NMDA autoreceptors
title_short Stereotyped initiation of retinal waves by bipolar cells via presynaptic NMDA autoreceptors
title_full Stereotyped initiation of retinal waves by bipolar cells via presynaptic NMDA autoreceptors
title_fullStr Stereotyped initiation of retinal waves by bipolar cells via presynaptic NMDA autoreceptors
title_full_unstemmed Stereotyped initiation of retinal waves by bipolar cells via presynaptic NMDA autoreceptors
title_sort stereotyped initiation of retinal waves by bipolar cells via presynaptic nmda autoreceptors
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-09-01
description Retinal waves are important for visual system development. However, the mechanism involved in their generation remains largely unknown. Here using in vivotwo-photon imaging the authors identify the presence of retinal waves in zebrafish larvae and find that they are initiated at bipolar cells via presynaptic NMDARs.
url https://doi.org/10.1038/ncomms12650
work_keys_str_mv AT rongweizhang stereotypedinitiationofretinalwavesbybipolarcellsviapresynapticnmdaautoreceptors
AT xiaoquanli stereotypedinitiationofretinalwavesbybipolarcellsviapresynapticnmdaautoreceptors
AT koichikawakami stereotypedinitiationofretinalwavesbybipolarcellsviapresynapticnmdaautoreceptors
AT jiulindu stereotypedinitiationofretinalwavesbybipolarcellsviapresynapticnmdaautoreceptors
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