Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1

Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1

Endoglin (ENG)/CD105 is an essential endothelial cell co-receptor of the transforming growth factor β (TGF-β) superfamily, mutated in hereditary hemorrhagic telangiectasia type 1 (HHT1) and involved in tumor angiogenesis and preeclampsia. Here, we present crystal structures of the ectodomain of huma...

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Bibliographic Details
Main Authors:	Takako Saito, Marcel Bokhove, Romina Croci, Sara Zamora-Caballero, Ling Han, Michelle Letarte, Daniele de Sanctis, Luca Jovine
Format:	Article
Language:	English
Published:	Elsevier 2017-05-01
Series:	Cell Reports
Subjects:	bone morphogenetic protein receptors cell surface receptors endoglin growth differentiation factor 2 hereditary hemorrhagic telangiectasia orphan domain protein interaction domains and motifs TGF-β superfamily proteins x-ray crystallography zona pellucida domain
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124717306368

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