HLA-mismatched allogeneic adoptive immune therapy in severely immunosuppressed AIDS patients

HLA-mismatched allogeneic adoptive immune therapy in severely immunosuppressed AIDS patients

Abstract Severely immunosuppressed AIDS patients with recurrent opportunistic infections (OIs) represent an unmet medical need even in the era of antiretroviral therapy (ART). Here we report the development of a human leukocyte antigen (HLA)-mismatched allogeneic adaptive immune therapy (AAIT) for s...

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Bibliographic Details
Main Authors: Ruonan Xu, Ji-Yuan Zhang, Bo Tu, Zhe Xu, Hui-Huang Huang, Lei Huang, Yan-Mei Jiao, Tao Yang, Chao Zhang, En-Qiang Qin, Tian-Jun Jiang, Yun-Bo Xie, Yuan-Yuan Li, Lei Jin, Chun-Bao Zhou, Ming Shi, Mei Guo, Hui-Sheng Ai, Linqi Zhang, Fu-Sheng Wang
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-021-00550-2

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