Zoledronic acid inhibits the growth of cancer stem cell derived from cervical cancer cell by attenuating their stemness phenotype and inducing apoptosis and cell cycle arrest through the Erk1/2 and Akt pathways

Zoledronic acid inhibits the growth of cancer stem cell derived from cervical cancer cell by attenuating their stemness phenotype and inducing apoptosis and cell cycle arrest through the Erk1/2 and Akt pathways

Abstract Background Zoledronic acid is the most potent osteoclast inhibitor and is widely used for advanced cancer patients with bone metastasis, but its role on cancer stem cells (CSCs) remains unclear. In the present study, we aimed to identify the stemness phenotypic characteristics of CSCs deriv...

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Bibliographic Details
Main Authors: Li Wang, Yanyang Liu, Yueling Zhou, Jiantao Wang, Li Tu, Zhen Sun, Xiujie Wang, Feng Luo
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Zoledronic acid
Cancer stem cell
Cervical cancer
Erk1/2
PI3K/Akt
Online Access:http://link.springer.com/article/10.1186/s13046-019-1109-z

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