Artificial Anti-HIV-1 Immunogen Comprising Epitopes of Broadly Neutralizing Antibodies 2F5, 10E8, and a Peptide Mimic of VRC01 Discontinuous Epitope

Artificial Anti-HIV-1 Immunogen Comprising Epitopes of Broadly Neutralizing Antibodies 2F5, 10E8, and a Peptide Mimic of VRC01 Discontinuous Epitope

The construction of artificial proteins using conservative B-cell and T-cell epitopes is believed to be a promising approach for a vaccine design against diverse viral infections. This article describes the development of an artificial HIV-1 immunogen using a polyepitope immunogen design strategy. W...

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Bibliographic Details
Main Authors: Andrey P. Rudometov, Anton N. Chikaev, Nadezhda B. Rudometova, Denis V. Antonets, Alexander A. Lomzov, Olga N. Kaplina, Alexander A. Ilyichev, Larisa I. Karpenko
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Vaccines
Subjects:
artificial protein
polyepitope B- and T-cell HIV-1 immunogen
epitopes of broadly neutralizing HIV-1 antibodies
peptide mimic of discontinuous epitope
immunogenicity
Online Access:https://www.mdpi.com/2076-393X/7/3/83

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https://www.mdpi.com/2076-393X/7/3/83

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