Properties of vitexin, tiliroside and 5,7-dihydroxy-3,8,4'-trimethoxy flavonoids in the treatment of diseases of the female reproductive system: an in silico approach

• Main Authors: Aleson Pereira de Sousa, Micaelly da Silva Oliveira, Diégina Araújo Fernandes, Maria Denise Leite Ferreira, Laísa Vilar Cordeiro, Helivaldo Diógenes da Silva Souza, Maria de Fátima Vanderlei de Souza, Hilzeth de Luna Freire Pessoa, Abrahão Alves de Oliveira Filho, Rita de Cássia da Silveira e Sá
• Format: Article
• Language: English
• Published: Universidade Federal de Rondonópolis 2021-02-01
• Series: Scientific Electronic Archives
• Subjects: fitofã¡rmacos; in silico; flavonoides
• Online Access: https://sea.ufr.edu.br/SEA/article/view/1313
• ISSN: 2316-9281; 2316-9281

Problems in the female reproductive system appear at the beginning of the reproductive cycle and persist until hormonal regulation in menopause. The drug therapies currently used can cause intolerance and susceptibility to other diseases, making it important to search for alternative therapeutic approaches that can be adopted during your reproductive life. Women use several species of plants to treat reproductive disorders. Some species are rich in bioactive molecules, such as flavonoids. The present study evaluated the bioactive in silico profile of three flavonoids: tyroside (Kaempferol-3-O-β-D- (6 ”-Ep-coumaryl) glucopyranoside), Pg-1 (5,7-dihydroxy-3,8, 4'-trimethoxy) and vitexin (5,7,4'-trihydroxyflavone-8-C-β-glucopyranoside). The predictive antineoplastic action on organs of the female reproductive system and the protective activity against pathogens (protozoa, bacteria, fungi and viruses) were addressed. The study showed that vitexin had antiviral activity, tiliroside had a better index of antibacterial and antifungal activity and Pg-1 had antiprotozoal activity. The incidence of neoplasms in the female reproductive system is due to hormonal variation and injuries possibly caused by recurrent infections. Therefore, flavonoids, which are considered phytoestrogens, can regulate hormonal disorder and help fight pathogens. Pg-1 had a better breast, uterine and ovarian anticancer potential, while tiliroside had a greater anticancer effect on the cervical region. Vitexin, despite its lower potential compared to other substances, also demonstrated satisfactory breast and cervical cancer activity. Therefore, these molecules can become important candidates for natural drugs with antimicrobial and anticancer activity, contributing to the use of non-synthetic products.