A Case of Effective Mepolizumab Induction Therapy for Severe Eosinophilic Granulomatosis with Polyangiitis Diagnosed by Eosinophilic Cholecystitis and Interstitial Nephritis

A Case of Effective Mepolizumab Induction Therapy for Severe Eosinophilic Granulomatosis with Polyangiitis Diagnosed by Eosinophilic Cholecystitis and Interstitial Nephritis

A 66-year-old man with a history of bronchial asthma and sinusitis was admitted with cholecystitis and peripheral neuropathy. The histopathological findings of the gallbladder revealed necrotic vasculitis and granulomatous inflammation with marked eosinophilic infiltration. Kidney biopsy also showed...

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Main Authors: Keita Hattori, Yuri Teramachi, Yoshinori Kobayashi, Takeshi Ito, Takatoshi Morinaga, Hirohumi Tamai, Yoshihiro Yamamoto
Format: Article
Language:English
Published: Hindawi Limited 2021-01-01
Series:Case Reports in Rheumatology
Online Access:http://dx.doi.org/10.1155/2021/6678893
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spelling doaj-612a6d9d19044df8b7c4d5d7ecf146092021-06-28T01:52:02ZengHindawi LimitedCase Reports in Rheumatology2090-68972021-01-01202110.1155/2021/6678893A Case of Effective Mepolizumab Induction Therapy for Severe Eosinophilic Granulomatosis with Polyangiitis Diagnosed by Eosinophilic Cholecystitis and Interstitial NephritisKeita Hattori0Yuri Teramachi1Yoshinori Kobayashi2Takeshi Ito3Takatoshi Morinaga4Hirohumi Tamai5Yoshihiro Yamamoto6Division of NephrologyDivision of NephrologyDivision of NephrologyDivision of NephrologyDivision of NephrologyDivision of NephrologyDivision of NephrologyA 66-year-old man with a history of bronchial asthma and sinusitis was admitted with cholecystitis and peripheral neuropathy. The histopathological findings of the gallbladder revealed necrotic vasculitis and granulomatous inflammation with marked eosinophilic infiltration. Kidney biopsy also showed marked eosinophilic infiltration in the tubulointerstitial area and eosinophilic tubulitis. He was diagnosed with eosinophilic granulomatosis with polyangiitis (EGPA) and treated with corticosteroids. However, he showed no response. Therefore, he was administered mepolizumab 300 mg, which resulted in clinical improvement, including normalization of the eosinophil and CRP levels. We herein describe the first case of successful induction therapy of EGPA using mepolizumab.http://dx.doi.org/10.1155/2021/6678893
collection DOAJ
language English
format Article
sources DOAJ
author Keita Hattori
Yuri Teramachi
Yoshinori Kobayashi
Takeshi Ito
Takatoshi Morinaga
Hirohumi Tamai
Yoshihiro Yamamoto
spellingShingle Keita Hattori
Yuri Teramachi
Yoshinori Kobayashi
Takeshi Ito
Takatoshi Morinaga
Hirohumi Tamai
Yoshihiro Yamamoto
A Case of Effective Mepolizumab Induction Therapy for Severe Eosinophilic Granulomatosis with Polyangiitis Diagnosed by Eosinophilic Cholecystitis and Interstitial Nephritis
Case Reports in Rheumatology
author_facet Keita Hattori
Yuri Teramachi
Yoshinori Kobayashi
Takeshi Ito
Takatoshi Morinaga
Hirohumi Tamai
Yoshihiro Yamamoto
author_sort Keita Hattori
title A Case of Effective Mepolizumab Induction Therapy for Severe Eosinophilic Granulomatosis with Polyangiitis Diagnosed by Eosinophilic Cholecystitis and Interstitial Nephritis
title_short A Case of Effective Mepolizumab Induction Therapy for Severe Eosinophilic Granulomatosis with Polyangiitis Diagnosed by Eosinophilic Cholecystitis and Interstitial Nephritis
title_full A Case of Effective Mepolizumab Induction Therapy for Severe Eosinophilic Granulomatosis with Polyangiitis Diagnosed by Eosinophilic Cholecystitis and Interstitial Nephritis
title_fullStr A Case of Effective Mepolizumab Induction Therapy for Severe Eosinophilic Granulomatosis with Polyangiitis Diagnosed by Eosinophilic Cholecystitis and Interstitial Nephritis
title_full_unstemmed A Case of Effective Mepolizumab Induction Therapy for Severe Eosinophilic Granulomatosis with Polyangiitis Diagnosed by Eosinophilic Cholecystitis and Interstitial Nephritis
title_sort case of effective mepolizumab induction therapy for severe eosinophilic granulomatosis with polyangiitis diagnosed by eosinophilic cholecystitis and interstitial nephritis
publisher Hindawi Limited
series Case Reports in Rheumatology
issn 2090-6897
publishDate 2021-01-01
description A 66-year-old man with a history of bronchial asthma and sinusitis was admitted with cholecystitis and peripheral neuropathy. The histopathological findings of the gallbladder revealed necrotic vasculitis and granulomatous inflammation with marked eosinophilic infiltration. Kidney biopsy also showed marked eosinophilic infiltration in the tubulointerstitial area and eosinophilic tubulitis. He was diagnosed with eosinophilic granulomatosis with polyangiitis (EGPA) and treated with corticosteroids. However, he showed no response. Therefore, he was administered mepolizumab 300 mg, which resulted in clinical improvement, including normalization of the eosinophil and CRP levels. We herein describe the first case of successful induction therapy of EGPA using mepolizumab.
url http://dx.doi.org/10.1155/2021/6678893
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