Closed-loop Administration of General Anaesthesia: From Sensor to Medical Device

• Main Authors: Jeanne Mathieu, Tavernier Benoît, Logier Régis, De Jonckheere Julien
• Format: Article
• Language: English
• Published: De Gruyter 2017-08-01
• Series: Pharmaceutical Technology in Hospital Pharmacy
• Subjects: monitoring; sensor; closed-loop; general anaesthesia; depth of hypnosis; analgesia/nociception balance; myorelaxation
• Online Access: https://doi.org/10.1515/pthp-2017-0017

Closed-loop administration devices for general anaesthesia have become a common subject of clinical research over the last decade and appear more and more acceptable in clinical practice. They encompass various therapeutic needs of the anesthetized patient, e. g. fluid administration, hypnotic and analgesic drug administration, myorelaxation. Multiple clinical trials involving closed-loop devices have underscored their safety, but data concerning their clinical benefit to the patient are still lacking. As the marketing of various devices increases, clinicians need to understand how comparisons between these devices can be made: the measure of performance error and wobble are technical but have also a clinical meaning, to which clinical outcomes can be added, such as drug consumption and maintenance of hemodynamic parameters (e. g. heart rate and blood pressure) within predefined ranges. Clinicians using closed-loop devices need especially to understand how various physiological signals lead to specific drug adaptations, which means that they switch from decision making to supervision of general anaesthesia.