Coupling of 5S RNP rotation with maturation of functional centers during large ribosomal subunit assembly

Coupling of 5S RNP rotation with maturation of functional centers during large ribosomal subunit assembly

As assembling 60S subunits transit from the nucleolus to the nucleoplasm, they undergo significant changes in protein composition and structure. Here, the authors provide a structural view of interconnected events during the middle steps of assembly that include the maturation of the central protube...

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Main Authors: Jelena Micic, Yu Li, Shan Wu, Daniel Wilson, Beril Tutuncuoglu, Ning Gao, John L. Woolford
Format: Article
Language:English
Published: Nature Publishing Group 2020-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17534-5
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spelling doaj-611c8aa58da84f4380a6473f6b8702a12021-08-01T11:40:17ZengNature Publishing GroupNature Communications2041-17232020-07-0111111610.1038/s41467-020-17534-5Coupling of 5S RNP rotation with maturation of functional centers during large ribosomal subunit assemblyJelena Micic0Yu Li1Shan Wu2Daniel Wilson3Beril Tutuncuoglu4Ning Gao5John L. Woolford6Department of Biological Sciences, Carnegie Mellon UniversityState Key Laboratory of Membrane Biology, School of Life Science, Tsinghua UniversityState Key Laboratory of Membrane Biology, School of Life Science, Tsinghua UniversityDepartment of Biological Sciences, Carnegie Mellon UniversityDepartment of Cellular and Molecular Pharmacology, University of CaliforniaState Key Laboratory of Membrane Biology, Peking-Tsinghua Center for Life Sciences, School of Life Sciences, Peking UniversityDepartment of Biological Sciences, Carnegie Mellon UniversityAs assembling 60S subunits transit from the nucleolus to the nucleoplasm, they undergo significant changes in protein composition and structure. Here, the authors provide a structural view of interconnected events during the middle steps of assembly that include the maturation of the central protuberance, the peptidyltransferase center and the nascent polypeptide exit tunnel.https://doi.org/10.1038/s41467-020-17534-5
collection DOAJ
language English
format Article
sources DOAJ
author Jelena Micic
Yu Li
Shan Wu
Daniel Wilson
Beril Tutuncuoglu
Ning Gao
John L. Woolford
spellingShingle Jelena Micic
Yu Li
Shan Wu
Daniel Wilson
Beril Tutuncuoglu
Ning Gao
John L. Woolford
Coupling of 5S RNP rotation with maturation of functional centers during large ribosomal subunit assembly
Nature Communications
author_facet Jelena Micic
Yu Li
Shan Wu
Daniel Wilson
Beril Tutuncuoglu
Ning Gao
John L. Woolford
author_sort Jelena Micic
title Coupling of 5S RNP rotation with maturation of functional centers during large ribosomal subunit assembly
title_short Coupling of 5S RNP rotation with maturation of functional centers during large ribosomal subunit assembly
title_full Coupling of 5S RNP rotation with maturation of functional centers during large ribosomal subunit assembly
title_fullStr Coupling of 5S RNP rotation with maturation of functional centers during large ribosomal subunit assembly
title_full_unstemmed Coupling of 5S RNP rotation with maturation of functional centers during large ribosomal subunit assembly
title_sort coupling of 5s rnp rotation with maturation of functional centers during large ribosomal subunit assembly
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-07-01
description As assembling 60S subunits transit from the nucleolus to the nucleoplasm, they undergo significant changes in protein composition and structure. Here, the authors provide a structural view of interconnected events during the middle steps of assembly that include the maturation of the central protuberance, the peptidyltransferase center and the nascent polypeptide exit tunnel.
url https://doi.org/10.1038/s41467-020-17534-5
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