Design, synthesis and biological evaluation of substituted pyrazoles endowed with brominated 4-methyl 7-hydroxy coumarin as new scaffolds against Alzheimer’s disease

Design, synthesis and biological evaluation of substituted pyrazoles endowed with brominated 4-methyl 7-hydroxy coumarin as new scaffolds against Alzheimer’s disease

Abstract Background The study aimed to design, synthesize and evaluate various brominated derivatives of 7-hydroxy coumarin as a new scaffold against Alzheimer’s disease by in vivo and in vitro models. A group of three novel pyrazoles endowed with brominated 7-hydroxy 4-methyl coumarin derivatives w...

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Bibliographic Details
Main Authors: Siju Ellickal Narayanan, Hariraj Narayanan, Minil Mukundan, Saranya Balan, C. P. Vishnupriya, Adarsh Gopinathan, Rajalekshmi Ganesan Rajamma, Akash Marathakam
Format: Article
Language:English
Published: SpringerOpen 2021-08-01
Series:Future Journal of Pharmaceutical Sciences
Subjects:
Acetylcholine esterase inhibition
MAO inhibition
Alzheimer’s disease, Coumarin derivatives
Online Access:https://doi.org/10.1186/s43094-021-00278-4

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