P53 Contributes to Cisplatin Induced Renal Oxidative Damage via Regulating P66shc and MnSOD

P53 Contributes to Cisplatin Induced Renal Oxidative Damage via Regulating P66shc and MnSOD

Background/Aims: Cisplatin is widely used to treat malignancies. However, its major limitation is the development of dose-dependent nephrotoxicity. The precise mechanisms of cisplatin-induced kidney damage remain unclear. Previous study demonstrated the central role of mitochondrial ROS (mtROS) in t...

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Bibliographic Details
Main Authors: Yanggang Yuan, Hui Wang, Yingyi Wu, Bo Zhang, Ningning Wang, Huijuan Mao, Changying Xing
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-10-01
Series:Cellular Physiology and Biochemistry
Subjects:
p53
MnSOD
p66shc
Cisplatin nephrotoxicity
Online Access:http://www.karger.com/Article/FullText/430247

Internet

http://www.karger.com/Article/FullText/430247

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