Effects of indirubin and isatin on cell viability, mutagenicity, genotoxicity and BAX/ERCC1 gene expression

Effects of indirubin and isatin on cell viability, mutagenicity, genotoxicity and BAX/ERCC1 gene expression

Context: Indigofera suffruticosa Miller (Fabaceae) and I. truxillensis Kunth produce compounds, such as isatin (ISA) and indirubin (IRN), which possess antitumour properties. Their effects in mammalian cells are still not very well understood. Objective: We evaluated the activities of ISA and/or IRN...

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Main Authors: Manoela Viar Fogaça, Priscila de Matos Cândido-Bacani, Lucas Milanez Benicio, Lara Martinelli Zapata, Priscilla de Freitas Cardoso, Marcelo Tempesta de Oliveira, Tamara Regina Calvo, Eliana Aparecida Varanda, Wagner Vilegas, Ilce Mara de Syllos Cólus
Format: Article
Language:English
Published: Taylor & Francis Group 2017-01-01
Series:Pharmaceutical Biology
Subjects:
indigofera suffruticosa
indigofera truxillensis
hela cells
cho-k1 cells
cytokinesis-blocked micronucleus assay
comet assay
apoptosis
Online Access:http://dx.doi.org/10.1080/13880209.2017.1354387

Internet

http://dx.doi.org/10.1080/13880209.2017.1354387

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