Trans ε viniferin decreases amyloid deposits and inflammation in a mouse transgenic Alzheimer model.

Trans ε viniferin decreases amyloid deposits and inflammation in a mouse transgenic Alzheimer model.

As Alzheimer's disease (AD) induces several cellular and molecular damages, it could be interesting to use multi-target molecules for therapeutics. We previously published that trans ε-viniferin induced the disaggregation of Aβ42 peptide and inhibited the inflammatory response in primary cellul...

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Main Authors: Martial Caillaud, Jérôme Guillard, Damien Richard, Serge Milin, Damien Chassaing, Marc Paccalin, Guylène Page, Agnès Rioux Bilan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0212663
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spelling doaj-6104f88045bb463db21808ccbf871d922021-03-03T20:52:22ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-01142e021266310.1371/journal.pone.0212663Trans ε viniferin decreases amyloid deposits and inflammation in a mouse transgenic Alzheimer model.Martial CaillaudJérôme GuillardDamien RichardSerge MilinDamien ChassaingMarc PaccalinGuylène PageAgnès Rioux BilanAs Alzheimer's disease (AD) induces several cellular and molecular damages, it could be interesting to use multi-target molecules for therapeutics. We previously published that trans ε-viniferin induced the disaggregation of Aβ42 peptide and inhibited the inflammatory response in primary cellular model of AD. Here, effects of this stilbenoid were evaluated in transgenic APPswePS1dE9 mice. We report that trans ε-viniferin could go through the blood brain barrier, reduces size and density of amyloid deposits and decreases reactivity of astrocytes and microglia, after a weekly intraperitoneal injection at 10 mg/kg from 3 to 6 months of age.https://doi.org/10.1371/journal.pone.0212663
collection DOAJ
language English
format Article
sources DOAJ
author Martial Caillaud
Jérôme Guillard
Damien Richard
Serge Milin
Damien Chassaing
Marc Paccalin
Guylène Page
Agnès Rioux Bilan
spellingShingle Martial Caillaud
Jérôme Guillard
Damien Richard
Serge Milin
Damien Chassaing
Marc Paccalin
Guylène Page
Agnès Rioux Bilan
Trans ε viniferin decreases amyloid deposits and inflammation in a mouse transgenic Alzheimer model.
PLoS ONE
author_facet Martial Caillaud
Jérôme Guillard
Damien Richard
Serge Milin
Damien Chassaing
Marc Paccalin
Guylène Page
Agnès Rioux Bilan
author_sort Martial Caillaud
title Trans ε viniferin decreases amyloid deposits and inflammation in a mouse transgenic Alzheimer model.
title_short Trans ε viniferin decreases amyloid deposits and inflammation in a mouse transgenic Alzheimer model.
title_full Trans ε viniferin decreases amyloid deposits and inflammation in a mouse transgenic Alzheimer model.
title_fullStr Trans ε viniferin decreases amyloid deposits and inflammation in a mouse transgenic Alzheimer model.
title_full_unstemmed Trans ε viniferin decreases amyloid deposits and inflammation in a mouse transgenic Alzheimer model.
title_sort trans ε viniferin decreases amyloid deposits and inflammation in a mouse transgenic alzheimer model.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2019-01-01
description As Alzheimer's disease (AD) induces several cellular and molecular damages, it could be interesting to use multi-target molecules for therapeutics. We previously published that trans ε-viniferin induced the disaggregation of Aβ42 peptide and inhibited the inflammatory response in primary cellular model of AD. Here, effects of this stilbenoid were evaluated in transgenic APPswePS1dE9 mice. We report that trans ε-viniferin could go through the blood brain barrier, reduces size and density of amyloid deposits and decreases reactivity of astrocytes and microglia, after a weekly intraperitoneal injection at 10 mg/kg from 3 to 6 months of age.
url https://doi.org/10.1371/journal.pone.0212663
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